microcrystalline cellulose msds fmc
/Resources 2 0 R Heavy metals, % NMT 0.001 All rights reserved. (AEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEM %)piQpFNnFu\4m4( ESE;m& %QL((((((((((((((((((((((((((((((((((((((((P3NhC For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. (Microcrystalline Cellulose Market Pr. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication. << PharmaCentral 2021 . /Type/Page Wu, K. Zuurman, H.W. MSDS Ref. The data shown below apply only to Avicel PH 101. >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . The most. PDF (2.77 mb) 2021 FMC Sustainability Report. BIOACCUMULATIVE POTENTIAL SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . Microcrystalline cellulose (C6H10O5)n is refined wood pulp. Performing this action will revert the following features to their default settings: Hooray! Created Date: 2/10/2020 8:51:41 PM . The cellulose molecule is formed through repeated condensation of cellobiose units. ). l~5C Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. Avicel co-processed grades are co-spray dried blends of Avicel microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends. X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe endobj FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . % : 51395-75-6 Date Approved: 01/31/2008 Revision No. 5 0 obj 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC aB s!YaxHWtGr"GQ 5S"fMS+_;x@@5 zjrK=;OA:il)b> e ei'wm~oh!=Z@Y:J0#8On`T./iC}^o%7KS"$ rf*Z;JTL-uOHH%%Z,029J_ ( endstream endobj 526 0 obj 465 endobj 527 0 obj << /Filter /FlateDecode /Length 526 0 R >> stream Fiber supplements can lessen the absorption of some . The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. 102331. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. CAS 9004-34-6, pH 5 - 7.5. Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. w !1AQaq"2B #3Rbr Alginates also function as actives in some anti-reflux products. Microcrystalline Cellulose / Avicel PH-102. Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe Microcrystalline Cellulose NF. (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. Home. MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. Delivering efficient and robust formulations. AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. . cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. Micro Crystalline Cellulose. Validity Area. POLYOX resins are nonionic polyethylene oxide solubility polymers. Browse Avicel PH-101 and related products at MilliporeSigma. endstream This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. CAS #: 9004-34-6 . 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents. Aqueous suspensions of microcrystalline cellulose have . : 160182 Date Approved: 05/25/2010 Revision No. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. (1962). It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. >> Aquacoat CPD is an aqueous dispersion of cellulose acetate phthalate used for enteric release applications. No. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. 130. The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. Microcrystalline cellulose is a commonly used excipient in the . We can send by Fedex, by ship or by plane according to international rules. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. Find answers in our support articles. MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . *r_ *?~4$ &0Y# Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . Watch Now. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. . Microcrystalline Cellulose Side Effects. Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. P}MFbN#[>r(y MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. A., and Smith, P. A. They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. >> /Parent 3 0 R Microcrystalline Cellulose / Avicel PH-102. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. Chemical Formula: (C6H10O5)n 1.4. FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Material Name: Estradiol Tablets Trade Name: RONFASE . Avicel Microcrystalline Cellulose Physical Properties. Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? No. INCI. These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. Cellulose microcrystalline for column chromatography. /Contents 4 0 R % Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. ( It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. Product Name Cellulose microcrystalline. Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. CAS No. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. lH5JWy}DgKRR"Fs The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. gac74 [#B6`Wnw7 HMo@9, U Q!R/1*;` High performance lubricant that brings more to the tablet. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. [FMC Study Number I92-1464]. FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . These grades have particle sizes ranging from <30 to approximately 200. It is, however, a good source of fibre. ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. A family of polysaccharide products that allow distinctive drug delivery solutions. Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. Combines good flow and high compactibility. Quantity: 1 700 kgs. Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. endobj . ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? << Medium size standard MCC grade, suited for the majority of directly compressible actives. It is also used in plaque assays for counting. Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . Microcrystalline Cellulose (MCC) Manufacturing Industry. It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. % Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. 4 0 obj microcrystalline cellulose and carboxymethylcellulose sodium NF, Ph. More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. /MediaBox [0 0 612 792] common form is used in vitamin supplements or tablets. %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. Safety Data Sheet for Cellulose microcrystalline 102331. Eur., JPE . 1 0 obj Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. 6 When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. YUMPU automatically turns print PDFs into web optimized ePapers that Google loves. Product and Company Identification . Microcrystalline Cellulose; Cellulose; Functions. 1.3. Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. CAS #: 9004-34-6 1.6. iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). B;vLZpHU%ChUyD+[ <> bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. The aqueous solution to barrier membrane coating. Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. Synergies to simplify formulation challenges and reduce operational costs. if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. Avicel PH-101. Synonyms: Cellulose, Cellulose powder, Cotton linters. Hi, let us know if you have any questions as you visit our website. 4 0 obj Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. Avicel Microcrystalline Cellulose: Chemical Identifiers. %PDF-1.4 Material safety data sheet - FMC Corporation. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. stream 0.25 - 0.37. Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. 6 0 obj $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? }o]X4]. : 9004-34-6 Date Approved: 01/31/2008 . Learn about FMC's industry leading goal of net-zero emissions by 2035. CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. This Microcrystalline Cellulose . GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. 8 0 obj Some substance identifiers may have been claimed confidential, or may . Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. No. With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. Molecular Weight null. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. Your file is uploaded and ready to be published. The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1.
microcrystalline cellulose msds fmc